产品货号：
Z33538
中文名称：
BIN1抗体
英文名称：
Anti-BIN1 Antibody (Clone#99F)
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BIN1 Antibody (Clone#99F) |
| 指标别名 | AMPH2;Amphiphysin II;Amphiphysin like protein;AMPHL;BIN1;bridging integrator 1;SH3P9 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | SDS-PAGE |
| 基因名称 | BIN1 |
| 克隆号 | 99F |
| 抗体来源 | Mouse |
| 抗体类型 | IgG |
| 免疫原 | Anti-BIN1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with BIN1 polypeptide followed by hybridoma development. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Anti-BIN1 was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above.BIN1 antibody is specific for human BIN1 protein.A BLAST analysis was used to suggest cross-reactivity with BIN1 from human and mouse sources based on 100% homology with the immunizing sequence.Cross-reactivity with BIN1 from other sources has not been determined. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Bin1 is a conserved member of the BAR family of genes that have been implicated in diverse cellular processes including endocytosis,actin organization,programmed cell death,stress responses,and transcriptional control.The first mammalian BAR protein to be discovered,Amphiphysin I (AmphI),was identified in an immunoscreen for proteins associated with the plasma membranes of synaptic neurons,functions in the control of clathrin-dependent synaptic vesicle endocytosis.The mammalian Bin1 gene was first identified in a two hybrid screen for polypeptides that bind to the N-terminal Myc box 1 (MB1) portion of the c-Myc oncoprotein.Bin1 is similar to AmphI in overall structure,with an N-terminal BAR domain and a C-terminal SH3 domain.However,the Bin1 gene is more complex than the AmphI gene,encoding at least seven different splice variants that differ widely in subcellular localization,tissue distribution,and ascribed functions.Alternate splicing of the Bin1 gene results in ten transcript variants encoding different isoform.Bin1 is expressed ubiquitously in mammalian cells.Certain splice variants of Bin1 are expressed in the neurons,muscle cells or tumor cells and play a role in cancer suppression.Studies in muscle cells suggest that Bin1 expression,structure,and localization are tightly regulated during muscle differentiation and suggested that Bin1 plays a functional role in the differentiation process.Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive;also known as autosomal recessive myotubular myopathy. |
| Uniprot ID | O00499 |
| 推荐稀释比 | ELISA:1:5000 - 1:50000 IF Microscopy:1:100～1:500 IP:10～100μL WB:1:500～1:1500 |
相关搜索：BIN1抗体，BIN1单抗，Anti-BIN1 Antibody (Clone#99F)